Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Self-amplifying RNA COVID-19 vaccine.

Wayne, Christopher J; Blakney, Anna K.

Cell ; 187(8): 1822-1822.e1, 2024 Apr 11.

Artigo em Inglês | MEDLINE | ID: mdl-38608649

2.

Trends in the synthetic polymer delivery of RNA.

Friesen, Josh J; Blakney, Anna K.

J Gene Med ; 26(2): e3672, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38380796

3.

Thermally Robust Solvent-Free Liquid Polyplexes for Heat-Shock Protection and Long-Term Room Temperature Storage of Therapeutic Nucleic Acids.

Chen, Yiyan; Lin, Xiaoyan; Liu, Xuhan; Liu, Yifan; Bui-Le, Liem; Blakney, Anna K; Yeow, Jonathan; Zhu, Yunqing; Stevens, Molly M; Shattock, Robin J; Chen, Rongjun; Brogan, Alex P S; Hallett, Jason P.

Biomacromolecules ; 25(5): 2965-2972, 2024 May 13.

Artigo em Inglês | MEDLINE | ID: mdl-38682378

4.

A tool for optimizing messenger RNA sequence.

Blakney, Anna K.

Nature ; 621(7978): 262-264, 2023 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-37253980

5.

Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach.

Ly, Han Han; Daniel, Simon; Soriano, Shekinah K V; Kis, Zoltán; Blakney, Anna K.

Mol Pharm ; 19(6): 1892-1905, 2022 06 06.

Artigo em Inglês | MEDLINE | ID: mdl-35604765

6.

Current Status and Future Perspectives on MRNA Drug Manufacturing.

Webb, Cameron; Ip, Shell; Bathula, Nuthan V; Popova, Petya; Soriano, Shekinah K V; Ly, Han Han; Eryilmaz, Burcu; Nguyen Huu, Viet Anh; Broadhead, Richard; Rabel, Martin; Villamagna, Ian; Abraham, Suraj; Raeesi, Vahid; Thomas, Anitha; Clarke, Samuel; Ramsay, Euan C; Perrie, Yvonne; Blakney, Anna K.

Mol Pharm ; 19(4): 1047-1058, 2022 04 04.

Artigo em Inglês | MEDLINE | ID: mdl-35238565

7.

Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA.

Blakney, Anna K; McKay, Paul F; Bouton, Clément R; Hu, Kai; Samnuan, Karnyart; Shattock, Robin J.

Mol Ther ; 29(3): 1174-1185, 2021 03 03.

Artigo em Inglês | MEDLINE | ID: mdl-33352107

8.

Mannosylated Poly(ethylene imine) Copolymers Enhance saRNA Uptake and Expression in Human Skin Explants.

Blakney, Anna K; Abdouni, Yamin; Yilmaz, Gokhan; Liu, Renjie; McKay, Paul F; Bouton, Clément R; Shattock, Robin J; Becer, C Remzi.

Biomacromolecules ; 21(6): 2482-2492, 2020 06 08.

Artigo em Inglês | MEDLINE | ID: mdl-32250603

9.

The In Vitro, Ex Vivo, and In Vivo Effect of Polymer Hydrophobicity on Charge-Reversible Vectors for Self-Amplifying RNA.

Gurnani, Pratik; Blakney, Anna K; Terracciano, Roberto; Petch, Joshua E; Blok, Andrew J; Bouton, Clément R; McKay, Paul F; Shattock, Robin J; Alexander, Cameron.

Biomacromolecules ; 21(8): 3242-3253, 2020 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-32644777

10.

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA.

Blakney, Anna K; McKay, Paul F; Yus, Bárbara Ibarzo; Aldon, Yoann; Shattock, Robin J.

Gene Ther ; 26(9): 363-372, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31300730

11.

DNA vaccines join the fight against COVID-19.

Blakney, Anna K; Bekker, Linda-Gail.

Lancet ; 399(10332): 1281-1282, 2022 04 02.

Artigo em Inglês | MEDLINE | ID: mdl-35366995

12.

One Size Does Not Fit All: The Effect of Chain Length and Charge Density of Poly(ethylene imine) Based Copolymers on Delivery of pDNA, mRNA, and RepRNA Polyplexes.

Blakney, Anna K; Yilmaz, Gokhan; McKay, Paul F; Becer, C Remzi; Shattock, Robin J.

Biomacromolecules ; 19(7): 2870-2879, 2018 07 09.

Artigo em Inglês | MEDLINE | ID: mdl-29698602

13.

Next-generation COVID-19 vaccines: here come the proteins.

Blakney, Anna K; McKay, Paul F.

Lancet ; 397(10275): 643-645, 2021 02 20.

Artigo em Inglês | MEDLINE | ID: mdl-33524312

14.

Voices in Molecular Pharmaceutics: Meet Dr. Anna Blakney, an Engineer Who Seeks To Develop the Next Generation of Gene Therapies.

Blakney, Anna K.

Mol Pharm ; 19(5): 1231-1232, 2022 05 02.

Artigo em Inglês | MEDLINE | ID: mdl-35491667

15.

Nanoparticle-Based ARV Drug Combinations for Synergistic Inhibition of Cell-Free and Cell-Cell HIV Transmission.

Jiang, Yonghou; Cao, Shijie; Bright, Danielle K; Bever, Alaina M; Blakney, Anna K; Suydam, Ian T; Woodrow, Kim A.

Mol Pharm ; 12(12): 4363-74, 2015 Dec 07.

Artigo em Inglês | MEDLINE | ID: mdl-26529558

16.

Intramyocardial injection of a synthetic hydrogel with delivery of bFGF and IGF1 in a rat model of ischemic cardiomyopathy.

Nelson, Devin M; Hashizume, Ryotaro; Yoshizumi, Tomo; Blakney, Anna K; Ma, Zuwei; Wagner, William R.

Biomacromolecules ; 15(1): 1-11, 2014 Jan 13.

Artigo em Inglês | MEDLINE | ID: mdl-24345287

17.

Immune response to the components of lipid nanoparticles for ribonucleic acid therapeutics.

Chen, Sunny P; Blakney, Anna K.

Curr Opin Biotechnol ; 85: 103049, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38118363

18.

Effect of in vitro transcription conditions on yield of high quality messenger and self-amplifying RNA.

Popova, Petya G; Lagace, Melissa A; Tang, George; Blakney, Anna K.

Eur J Pharm Biopharm ; 198: 114247, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38462138

19.

Clinical perspective on topical vaccination strategies.

G Popova, Petya; Chen, Sunny P; Liao, Suiyang; Sadarangani, Manish; Blakney, Anna K.

Adv Drug Deliv Rev ; 208: 115292, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38522725

20.

A duplex droplet digital PCR assay for absolute quantification and characterization of long self-amplifying RNA.

Casmil, Irafasha C; Huang, Cynthia; Blakney, Anna K.

Sci Rep ; 13(1): 19050, 2023 11 03.

Artigo em Inglês | MEDLINE | ID: mdl-37923834

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